Neurons derived from sporadic Alzheimer’s disease iPSCs reveal elevated TAU hyperphosphorylation, increased amyloid levels, and GSK3B activation

Neurons derived from sporadic Alzheimer’s disease iPSCs reveal elevated TAU hyperphosphorylation, increased amyloid levels, and GSK3B activation

Abstract Background Alzheimer’s disease (AD) is the most common type of dementia, affecting one in eight adults over 65 years of age. The majority of AD cases are sporadic, with unknown etiology, and only 5% of all patients with AD present the familial monogenic form of the disease. In the present s...

Full description

Bibliographic Details
Main Authors: Anna Ochalek, Balázs Mihalik, Hasan X. Avci, Abinaya Chandrasekaran, Annamária Téglási, István Bock, Maria Lo Giudice, Zsuzsanna Táncos, Kinga Molnár, Lajos László, Jørgen E. Nielsen, Bjørn Holst, Kristine Freude, Poul Hyttel, Julianna Kobolák, András Dinnyés
Format: Article
Language:English
Published: BMC 2017-12-01
Series:Alzheimer’s Research & Therapy
Subjects:
Familial Alzheimer’s disease
Sporadic Alzheimer’s disease
Induced pluripotent stem cells
Amyloid β
TAU pathology
Hyperphosphorylation
Online Access:http://link.springer.com/article/10.1186/s13195-017-0317-z

Internet

http://link.springer.com/article/10.1186/s13195-017-0317-z

Similar Items