Maternal Immune Activation Affects Hippocampal Excitatory and Inhibitory Synaptic Transmission in Offspring From an Early Developmental Period to Adulthood

Maternal Immune Activation Affects Hippocampal Excitatory and Inhibitory Synaptic Transmission in Offspring From an Early Developmental Period to Adulthood

One of the risk factors for schizophrenia is maternal infection. We have previously shown that Polyriboinosinic-polyribocytidylic acid (poly I:C) induced maternal immune activation in mice caused histological changes in the hippocampal CA1 area of offspring during the developmental period and impair...

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Bibliographic Details
Main Authors: Keiju Nakagawa, Hiroki Yoshino, Yoichi Ogawa, Kazuhiko Yamamuro, Sohei Kimoto, Yoshinobu Noriyama, Manabu Makinodan, Masayuki Yamashita, Yasuhiko Saito, Toshifumi Kishimoto
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Cellular Neuroscience
Subjects:
CA1
synaptic transmission
maternal infection
poly I:C
schizophrenia
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2020.00241/full

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https://www.frontiersin.org/article/10.3389/fncel.2020.00241/full

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