Ubiquitin Specific Peptidase 22 Regulates Histone H2B Mono-Ubiquitination and Exhibits Both Oncogenic and Tumor Suppressor Roles in Cancer

Ubiquitin Specific Peptidase 22 Regulates Histone H2B Mono-Ubiquitination and Exhibits Both Oncogenic and Tumor Suppressor Roles in Cancer

Ubiquitin-Specific Peptidase 22 (USP22) is a ubiquitin hydrolase, notably catalyzing the removal of the mono-ubiquitin moiety from histone H2B (H2Bub1). Frequent overexpression of USP22 has been observed in various cancer types and is associated with poor patient prognosis. Multiple mechanisms have...

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Bibliographic Details
Main Authors: Lucile M-P. Jeusset, Kirk J. McManus
Format: Article
Language:English
Published: MDPI AG 2017-12-01
Series:Cancers
Subjects:
USP22
H2Bub1
cancer
SAGA complex
DUBm
genome stability
DNA double-strand break repair
chromosome instability
cell cycle regulation
precision medicine
Online Access:https://www.mdpi.com/2072-6694/9/12/167

Internet

https://www.mdpi.com/2072-6694/9/12/167

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