Ubiquitin Specific Peptidase 22 Regulates Histone H2B Mono-Ubiquitination and Exhibits Both Oncogenic and Tumor Suppressor Roles in Cancer
Ubiquitin-Specific Peptidase 22 (USP22) is a ubiquitin hydrolase, notably catalyzing the removal of the mono-ubiquitin moiety from histone H2B (H2Bub1). Frequent overexpression of USP22 has been observed in various cancer types and is associated with poor patient prognosis. Multiple mechanisms have...
Main Authors: | , |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2017-12-01
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Series: | Cancers |
Subjects: | |
Online Access: | https://www.mdpi.com/2072-6694/9/12/167 |