Hsp70-associated chaperones have a critical role in buffering protein production costs

Hsp70-associated chaperones have a critical role in buffering protein production costs

Proteins are necessary for cellular growth. Concurrently, however, protein production has high energetic demands associated with transcription and translation. Here, we propose that activity of molecular chaperones shape protein burden, that is the fitness costs associated with expression of unneede...

Full description

Bibliographic Details
Main Authors: Zoltán Farkas, Dorottya Kalapis, Zoltán Bódi, Béla Szamecz, Andreea Daraba, Karola Almási, Károly Kovács, Gábor Boross, Ferenc Pál, Péter Horváth, Tamás Balassa, Csaba Molnár, Aladár Pettkó-Szandtner, Éva Klement, Edit Rutkai, Attila Szvetnik, Balázs Papp, Csaba Pál
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-01-01
Series:eLife
Subjects:
protein burden
genetic interaction
chaperone overload
Online Access:https://elifesciences.org/articles/29845

Internet

https://elifesciences.org/articles/29845

Similar Items