Genome-wide analysis of Mycobacterium tuberculosis polymorphisms reveals lineage-specific associations with drug resistance

Genome-wide analysis of Mycobacterium tuberculosis polymorphisms reveals lineage-specific associations with drug resistance

Abstract Background Continuing evolution of the Mycobacterium tuberculosis (Mtb) complex genomes associated with resistance to anti-tuberculosis drugs is threatening tuberculosis disease control efforts. Both multi- and extensively drug resistant Mtb (MDR and XDR, respectively) are increasing in pre...

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Bibliographic Details
Main Authors: Yaa E. A. Oppong, Jody Phelan, João Perdigão, Diana Machado, Anabela Miranda, Isabel Portugal, Miguel Viveiros, Taane G. Clark, Martin L. Hibberd
Format: Article
Language:English
Published: BMC 2019-03-01
Series:BMC Genomics
Subjects:
Drug resistance
Evolution
Mutations
Mycobacterium tuberculosis
Tuberculosis
Online Access:http://link.springer.com/article/10.1186/s12864-019-5615-3

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http://link.springer.com/article/10.1186/s12864-019-5615-3

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