Degradomics-Based Analysis of Tetanus Toxoids as a Quality Control Assay

Degradomics-Based Analysis of Tetanus Toxoids as a Quality Control Assay

Currently, batch release of toxoid vaccines, such as diphtheria and tetanus toxoid, requires animal tests to confirm safety and immunogenicity. Efforts are being made to replace these tests with in vitro assays in a consistency approach. Limitations of current in vitro assays include the need for re...

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Bibliographic Details
Main Authors: Thomas J. M. Michiels, Wichard Tilstra, Martin R. J. Hamzink, Justin W. de Ridder, Maarten Danial, Hugo D. Meiring, Gideon F. A. Kersten, Wim Jiskoot, Bernard Metz
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Vaccines
Subjects:
degradomics
mass spectrometry
tetanus toxoid
vaccines
proteomics
3Rs
Online Access:https://www.mdpi.com/2076-393X/8/4/712

Internet

https://www.mdpi.com/2076-393X/8/4/712

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