Drosophila melanogaster as a function-based high-throughput screening model for antinephrolithiasis agents in kidney stone patients

Drosophila melanogaster as a function-based high-throughput screening model for antinephrolithiasis agents in kidney stone patients

Kidney stone disease involves the aggregation of stone-forming salts consequent to solute supersaturation in urine. The development of novel therapeutic agents for this predominantly metabolic and biochemical disorder have been hampered by the lack of a practical pre-clinical model amenable to drug...

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Bibliographic Details
Main Authors: Sohrab N. Ali, Thamara K. Dayarathna, Aymon N. Ali, Tijani Osumah, Mohamed Ahmed, Tyler T. Cooper, Nicholas E. Power, Dongxing Zhang, Dajung Kim, Rachel Kim, Andre St. Amant, Jinqiang Hou, Thomas Tailly, Jun Yang, Len Luyt, Paul A. Spagnuolo, Jeremy P. Burton, Hassan Razvi, Hon S. Leong
Format: Article
Language:English
Published: The Company of Biologists 2018-11-01
Series:Disease Models & Mechanisms
Subjects:
Drosophila melanogaster
Nephrolithiasis
Calcium oxalate
Fluorescent bisphosphonate
Intravital imaging
Online Access:http://dmm.biologists.org/content/11/11/dmm035873

Internet

http://dmm.biologists.org/content/11/11/dmm035873

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