Proviral Quasispecies Diversity Is Not Associated With Virologic Breakthrough or CD4+ T Cell Loss in HIV-1 Elite Controllers

Proviral Quasispecies Diversity Is Not Associated With Virologic Breakthrough or CD4+ T Cell Loss in HIV-1 Elite Controllers

Elite controllers (EC) are able to control HIV-1 replication to extremely low levels (<50 HIV-1 RNA copies/mL) in the absence of antiretroviral therapy. However, some EC experience CD4+ T cell loss and/or lose their ability to control HIV-1 over the course of infection. High levels of HIV-1 e...

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Bibliographic Details
Main Authors: Suwellen S. D. de Azevedo, Fernanda H. Côrtes, Edson Delatorre, Marcelo Ribeiro-Alves, Brenda Hoagland, Beatriz Grinsztejn, Valdilea G. Veloso, Mariza G. Morgado, Gonzalo Bello
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Microbiology
Subjects:
elite controllers
HIV proviral diversity
plasma biomarkers
CD4+ T cell loss
breakthrough viremia
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2019.00673/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2019.00673/full

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