Impaired pattern separation in Tg2576 mice is associated with hyperexcitable dentate gyrus caused by Kv4.1 downregulation

Impaired pattern separation in Tg2576 mice is associated with hyperexcitable dentate gyrus caused by Kv4.1 downregulation

Abstract Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that causes memory loss. Most AD researches have focused on neurodegeneration mechanisms. Considering that neurodegenerative changes are not reversible, understanding early functional changes before neurodegeneration is cr...

Full description

Bibliographic Details
Main Authors: Kyung-Ran Kim, Yoonsub Kim, Hyeon-Ju Jeong, Jong-Sun Kang, Sang Hun Lee, Yujin Kim, Suk-Ho Lee, Won-Kyung Ho
Format: Article
Language:English
Published: BMC 2021-03-01
Series:Molecular Brain
Subjects:
Tg2676
Intrinsic excitability
Dentate gyrus
Kv4.1
Alzheimer’s disease
Online Access:https://doi.org/10.1186/s13041-021-00774-x

Internet

https://doi.org/10.1186/s13041-021-00774-x

Similar Items