Mutant FUS causes DNA ligation defects to inhibit oxidative damage repair in Amyotrophic Lateral Sclerosis

Mutant FUS causes DNA ligation defects to inhibit oxidative damage repair in Amyotrophic Lateral Sclerosis

Impairment of DNA repair has been associated with neurodegeneration. Here the authors investigate the mechanisms of defects in repair caused by mutations in the RNA/DNA binding protein FUS in amyotrophic lateral sclerosis and elucidate its role in the DNA ligation during DNA single-strand break repa...

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Bibliographic Details
Main Authors: Haibo Wang, Wenting Guo, Joy Mitra, Pavana M. Hegde, Tijs Vandoorne, Bradley J. Eckelmann, Sankar Mitra, Alan E. Tomkinson, Ludo Van Den Bosch, Muralidhar L. Hegde
Format: Article
Language:English
Published: Nature Publishing Group 2018-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-06111-6

Internet

https://doi.org/10.1038/s41467-018-06111-6

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