Modulation of doxorubicin-induced expression of the multidrug resistance gene in breast cancer cells by diltiazem and protection against cardiotoxicity in experimental animals

Modulation of doxorubicin-induced expression of the multidrug resistance gene in breast cancer cells by diltiazem and protection against cardiotoxicity in experimental animals

Abstract Background Doxorubicin (DOX) is one of the most important anticancer agents used in treating breast cancer. However, chronic cardiotoxicity and multidrug resistance limit the chemotherapeutic use of DOX. Methods This study aimed to evaluate the capability of calcium channel blocker diltiaze...

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Bibliographic Details
Main Authors: Hamdan S. Al-malky, Abdel-Moneim M. Osman, Zoheir A. Damanhouri, Huda M. Alkreathy, Jumana Y. Al Aama, Wafaa S. Ramadan, Ali A. Al Qahtani, Hadiah B. Al Mahdi
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Cancer Cell International
Subjects:
Doxorubicin
Diltiazem
MCF-7 cells
MDR
Cardiotoxicity
Online Access:http://link.springer.com/article/10.1186/s12935-019-0912-0

Internet

http://link.springer.com/article/10.1186/s12935-019-0912-0

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