First discovery and stucture-activity relationship study of phenanthroquinolizidines as novel antiviral agents against tobacco mosaic virus (TMV).

A series of phenanthroquinolizidine alkaloids 1-24 were prepared and first evaluated for their antiviral activity against tobacco mosaic virus (TMV). The bioassay results showed that most of these compounds exhibited good to excellent in vivo anti-TMV activity, of which compounds 1, 2, 15 and 16 dis...

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Bibliographic Details
Main Authors: Ziwen Wang, Anzheng Feng, Mingbo Cui, Yuxiu Liu, Lizhong Wang, Qingmin Wang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3532156?pdf=render