BMX-ARHGAP fusion protein maintains the tumorigenicity of gastric cancer stem cells by activating the JAK/STAT3 signaling pathway

BMX-ARHGAP fusion protein maintains the tumorigenicity of gastric cancer stem cells by activating the JAK/STAT3 signaling pathway

Abstract Background Cancer stem cells (CSCs), drug-resistant cancer cell subsets, are known to be responsible for tumor metastasis and relapse. The JAK/STAT pathway, activated by SH2 domain, is known to regulate the tumor growth in gastric cancer (GC). Now, this study was designed to examine whether...

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Bibliographic Details
Main Authors: Xiao-Feng Xu, Feng Gao, Jian-Jiang Wang, Cong Long, Xing Chen, Lan Tao, Liu Yang, Li Ding, Yong Ji
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Cancer Cell International
Subjects:
BMX-ARHGAP
Src homology region 2
Gastric cancer
JAK/STAT3 signaling pathway
Cancer stem cells
Online Access:http://link.springer.com/article/10.1186/s12935-019-0847-5

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http://link.springer.com/article/10.1186/s12935-019-0847-5

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