Genetic Removal of the CH1 Exon Enables the Production of Heavy Chain-Only IgG in Mice

Genetic Removal of the CH1 Exon Enables the Production of Heavy Chain-Only IgG in Mice

Nano-antibodies possess great potential in many applications. However, they are naturally derived from heavy chain-only antibodies (HcAbs), which lack light chains and the CH1 domain, and are only found in camelids and sharks. In this study, we investigated whether the precise genetic removal of the...

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Bibliographic Details
Main Authors: Tianyi Zhang, Xueqian Cheng, Di Yu, Fuyu Lin, Ning Hou, Xuan Cheng, Shanshan Hao, Jingjing Wei, Li Ma, Yanbin Fu, Yonghe Ma, Liming Ren, Haitang Han, Shuyang Yu, Xiao Yang, Yaofeng Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Immunology
Subjects:
HcAbs
nanobody
CH1 domain
mouse
phage display
single domain antibodies
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02202/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02202/full

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