Molecular determinants of WNT9b responsiveness in nephron progenitor cells.

Primed nephron progenitor cells (NPCs) appear in metanephric mesenchyme by E11.5 and differentiate in response to the inductive WNT9b signal from the ureteric bud. However, the NPC WNT-receptor complex is unknown. We obtained M15 cells from E10.5 mesonephric mesenchyme and systematically analyzed co...

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Bibliographic Details
Main Authors: Kyle K Dickinson, Leah C Hammond, Courtney M Karner, Nicholas D Hastie, Thomas J Carroll, Paul Goodyer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0215139