Validation of the zebrafish pentylenetetrazol seizure model: locomotor versus electrographic responses to antiepileptic drugs.

Validation of the zebrafish pentylenetetrazol seizure model: locomotor versus electrographic responses to antiepileptic drugs.

Zebrafish have recently emerged as an attractive in vivo model for epilepsy. Seven-day-old zebrafish larvae exposed to the GABA(A) antagonist pentylenetetrazol (PTZ) exhibit increased locomotor activity, seizure-like behavior, and epileptiform electrographic activity. A previous study showed that 12...

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Bibliographic Details
Main Authors: Tatiana Afrikanova, Ann-Sophie K Serruys, Olivia E M Buenafe, Ralph Clinckers, Ilse Smolders, Peter A M de Witte, Alexander D Crawford, Camila V Esguerra
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23342097/?tool=EBI

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23342097/?tool=EBI

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