Screening of Peptide Ligands for Pyrroloquinoline Quinone Glucose Dehydrogenase Using Antagonistic Template-Based Biopanning

Screening of Peptide Ligands for Pyrroloquinoline Quinone Glucose Dehydrogenase Using Antagonistic Template-Based Biopanning

We have developed a novel method, antagonistic template-based biopanning, for screening peptide ligands specifically recognizing local tertiary protein structures. We chose water-soluble pyrroloquinoline quinone (PQQ) glucose dehydrogenase (GDH-B) as a model enzyme for this screening. Two GDH-B muta...

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Bibliographic Details
Main Authors: Koichi Abe, Wataru Yoshida, Kotaro Terada, Yukiko Yagi-Ishii, Stefano Ferri, Kazunori Ikebukuro, Koji Sode
Format: Article
Language:English
Published: MDPI AG 2013-11-01
Series:International Journal of Molecular Sciences
Subjects:
peptide ligand
phage display
site-directed
inhibitor
Online Access:http://www.mdpi.com/1422-0067/14/12/23244

Internet

http://www.mdpi.com/1422-0067/14/12/23244

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