Signalling pathways in UHRF1-dependent regulation of tumor suppressor genes in cancer

Signalling pathways in UHRF1-dependent regulation of tumor suppressor genes in cancer

Abstract Epigenetic silencing of tumor suppressor genes (TSGs) through DNA methylation and histone changes is a main hallmark of cancer. Ubiquitin-like with PHD and RING Finger domains 1 (UHRF1) is a potent oncogene overexpressed in various solid and haematological tumors and its high expression lev...

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Bibliographic Details
Main Authors: Mahmoud Alhosin, Ziad Omran, Mazin A. Zamzami, Abdulrahman L. Al-Malki, Hani Choudhry, Marc Mousli, Christian Bronner
Format: Article
Language:English
Published: BMC 2016-11-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Epigenetic
DNA methylation
p16INK4A
p53
p73
Tumor suppressor genes
Online Access:http://link.springer.com/article/10.1186/s13046-016-0453-5

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http://link.springer.com/article/10.1186/s13046-016-0453-5

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