Angiotensin type 1a receptors in the forebrain subfornical organ facilitate leptin-induced weight loss through brown adipose tissue thermogenesis

Angiotensin type 1a receptors in the forebrain subfornical organ facilitate leptin-induced weight loss through brown adipose tissue thermogenesis

Objective: Elevations in brain angiotensin-II cause increased energy expenditure and a lean phenotype. Interestingly, the metabolic effects of increased brain angiotensin-II mimic the actions of leptin, suggesting an interaction between the two systems. Here we demonstrate that angiotensin-type 1a...

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Bibliographic Details
Main Authors: Colin N. Young, Donald A. Morgan, Scott D. Butler, Kamal Rahmouni, Susan B. Gurley, Thomas M. Coffman, Allyn L. Mark, Robin L. Davisson
Format: Article
Language:English
Published: Elsevier 2015-04-01
Series:Molecular Metabolism
Subjects:
Leptin
Brown adipose tissue
Brain
Angiotensin
Sympathetic nervous system
Metabolic regulation
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877815000204

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http://www.sciencedirect.com/science/article/pii/S2212877815000204

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