Regional Delivery of Anti-PD-1 Agent for Colorectal Liver Metastases Improves Therapeutic Index and Anti-Tumor Activity

Regional Delivery of Anti-PD-1 Agent for Colorectal Liver Metastases Improves Therapeutic Index and Anti-Tumor Activity

Metastatic liver tumors have presented challenges with the use of checkpoint inhibitors (CPIs), with only limited success. We hypothesize that regional delivery (RD) of CPIs can improve activity in the liver and minimize systemic exposure, thereby reducing immune-related adverse events (irAE). Using...

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Bibliographic Details
Main Authors: Louis F. Chai, John C. Hardaway, Kara R. Heatherton, Kyle P. O’Connell, Mikayla C. Lopes, Benjamin A. Rabinowitz, Chandra C. Ghosh, Prajna Guha, David Jaroch, Bryan F. Cox, Steven C. Katz
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Vaccines
Subjects:
liver metastasis
regional delivery
PD-1
PD-L1
myeloid-derived suppressor cells
systemic delivery
Online Access:https://www.mdpi.com/2076-393X/9/8/807

Internet

https://www.mdpi.com/2076-393X/9/8/807

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