MEN1 deficiency leads to neuroendocrine differentiation of lung cancer and disrupts the DNA damage response

MEN1 deficiency leads to neuroendocrine differentiation of lung cancer and disrupts the DNA damage response

Loss ofMEN1 results in an inherited multiple endocrine neoplastic type 1 syndrome. Here, the authors generate an alveolar type II cell MEN1 knockout mouse model and show that on a Kras mutant background the mice develop lung tumors with features of neuroendocrine differentiation.

Bibliographic Details
Main Authors: Huan Qiu, Bang-Ming Jin, Zhan-Feng Wang, Bin Xu, Qi-Fan Zheng, Li Zhang, Ling-Yu Zhu, Shuang Shi, Jun-Bo Yuan, Xiao Lin, Shu-Bin Gao, Guang-Hui Jin
Format: Article
Language:English
Published: Nature Publishing Group 2020-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-14614-4

Internet

https://doi.org/10.1038/s41467-020-14614-4

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