Disruption of IL-33 Signaling Limits Early CD8+ T Cell Effector Function Leading to Exhaustion in Murine Hemophagocytic Lymphohistiocytosis

Disruption of IL-33 Signaling Limits Early CD8+ T Cell Effector Function Leading to Exhaustion in Murine Hemophagocytic Lymphohistiocytosis

Danger signals mediated through ST2, the interleukin-33 (IL-33) receptor, amplify CD8+ T cell-mediated inflammation in the murine model of familial hemophagocytic lymphohistiocytosis type 2 (FHL2), and blockade of ST2 provides a potential therapeutic strategy in this disease. However, the long-term...

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Bibliographic Details
Main Authors: Julia E. Rood, Thomas N. Burn, Vanessa Neal, Niansheng Chu, Edward M. Behrens
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Immunology
Subjects:
interleukin-33
ST2
hemophagocytic lymphohistiocytosis
CD8+ T cells
exhaustion
perforin
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02642/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02642/full

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