Suzuki–Miyaura Reactions of (4-bromophenyl)-4,6-dichloropyrimidine through Commercially Available Palladium Catalyst: Synthesis, Optimization and Their Structural Aspects Identification through Computational Studies

Suzuki–Miyaura Reactions of (4-bromophenyl)-4,6-dichloropyrimidine through Commercially Available Palladium Catalyst: Synthesis, Optimization and Their Structural Aspects Identification through Computational Studies

5-(4-bromophenyl)-4,6-dichloropyrimidine was arylated with several aryl/heteroaryl boronic acids via the Suzuki cross-coupling reaction by using Pd(0) catalyst to yield novel pyrimidine analogs (<b>3a-h</b>). It was optimized so that good yields were obtained when 5 mol % Pd(PPh3)4 was u...

Full description

Bibliographic Details
Main Authors: Ayesha Malik, Nasir Rasool, Iram Kanwal, Muhammad Ali Hashmi, Ameer Fawad Zahoor, Gulraiz Ahmad, Ataf Ali Altaf, Syed Adnan Ali Shah, Sadia Sultan, Zainul Amiruddin Zakaria
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Processes
Subjects:
Suzuki–Miyaura
Pd catalyst
DFT
reactivity descriptors
FMO
Online Access:https://www.mdpi.com/2227-9717/8/11/1342

Internet

https://www.mdpi.com/2227-9717/8/11/1342

Similar Items