Ligand-Based Stability Changes in Duplex DNA Measured with a Microscale Electrochemical Platform

Ligand-Based Stability Changes in Duplex DNA Measured with a Microscale Electrochemical Platform

Development of technologies for rapid screening of DNA secondary structure thermal stability and the effects on stability for binding of small molecule drugs is important to the drug discovery process. In this report, we describe the capabilities of an electrochemical, microdevice-based approach for...

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Bibliographic Details
Main Authors: Sarah M. Robinson, Zuliang Shen, Jon R. Askim, Christopher B. Montgomery, Herman O. Sintim, Steve Semancik
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:Biosensors
Subjects:
DNA
electrochemical sensor
ligand-based stabilization
melting profiles
microfabrication
microheater
rapid temperature control
square wave voltammetry
Online Access:https://www.mdpi.com/2079-6374/9/2/54

Internet

https://www.mdpi.com/2079-6374/9/2/54

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