Methylglyoxal Binding to Bovine Liver Catalase Results in Loss of Activity and Heme Dislocation

Glycation, the non-enzymatic attachment of glucose to protein, is one of the important events in the pathophysiology of diabetes mellitus, Alzheimer’s, Parkinson’s and other diseases. Methylglyoxal (MG), a dicarbonyl compound formed during glycation, monosaccharide autoxidation, and metabolism is el...

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Bibliographic Details
Main Authors: Subramanian Sivakami, Sejal A Shah, George Suji, Vikrant M Bhor, Ahmad Ali
Format: Article
Language:English
Published: Shahid Beheshti University of Medical Sciences 2019-09-01
Series:Trends in Peptide and Protein Sciences
Subjects:
Online Access:https://journals.sbmu.ac.ir/protein/article/view/26261