Receptor for Advanced Glycation End Products Antagonism Blunts Kidney Damage in Transgenic Townes Sickle Mice

Receptor for Advanced Glycation End Products Antagonism Blunts Kidney Damage in Transgenic Townes Sickle Mice

A large proportion of adult patients with sickle cell disease (SCD) develops kidney disease and is at a high risk of mortality. The contribution of advanced glycation end products and their receptor (AGE/RAGE) axis has been established in the pathogenesis of multiple kidney diseases. The aim of the...

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Bibliographic Details
Main Authors: Emmanuelle Charrin, Camille Faes, Amandine Sotiaux, Sarah Skinner, Vincent Pialoux, Philippe Joly, Philippe Connes, Cyril Martin
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Physiology
Subjects:
sickle cell disease
RAGEs
kidney
Townes mice
oxidative stress
inflammation
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2019.00880/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2019.00880/full

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