Guanylate binding proteins directly attack Toxoplasma gondii via supramolecular complexes

Guanylate binding proteins directly attack Toxoplasma gondii via supramolecular complexes

GBPs are essential for immunity against intracellular pathogens, especially for Toxoplasma gondii control. Here, the molecular interactions of murine GBPs (mGBP1/2/3/5/6), homo- and hetero-multimerization properties of mGBP2 and its function in parasite killing were investigated by mutational, Multi...

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Bibliographic Details
Main Authors: Elisabeth Kravets, Daniel Degrandi, Qijun Ma, Thomas-Otavio Peulen, Verena Klümpers, Suren Felekyan, Ralf Kühnemuth, Stefanie Weidtkamp-Peters, Claus AM Seidel, Klaus Pfeffer
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-01-01
Series:eLife
Subjects:
host-pathogen interaction
cell-autonomous immunity
guanylate-binding proteins
Förster resonance energy transfer
multiparameter fluorescence image spectroscopy
Online Access:https://elifesciences.org/articles/11479

Internet

https://elifesciences.org/articles/11479

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