Tetramethylpyrazine (TMP) switches energy signalling from the PKCζ-GLUT4-glucose pathway back to the SIRT1-CD36-fatty acid pathway similar to resveratrol to ameliorate cardiac myocyte lipotoxicity

Tetramethylpyrazine (TMP) switches energy signalling from the PKCζ-GLUT4-glucose pathway back to the SIRT1-CD36-fatty acid pathway similar to resveratrol to ameliorate cardiac myocyte lipotoxicity

Fatty acids and glucose are the main energy sources for the heart. Energy metabolic imbalance can cause many heart dysfunctions. Cardiomyocytes can switch to using fatty acids or glucose as an energy source. Palmitic acid (PA) treatment induces lipoptoxity and loss of mitochondrial function. We util...

Full description

Bibliographic Details
Main Authors: Yeh-Peng Chen, Chia-Wen Tsai, Dennis Jine-Yuan Hsieh, Chia-Yao Shen, Tsung-Jung Ho, V. Vijaya Padma, Wei- Wen Kuo, Chih-Yang Huang
Format: Article
Language:English
Published: Elsevier 2015-12-01
Series:Journal of Functional Foods
Subjects:
Tetramethylpyrazine (TMP)
Resveratrol
Energy metabolism impaired pathways
Cardiomyoblast lipotoxicity
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464615004946

Internet

http://www.sciencedirect.com/science/article/pii/S1756464615004946

Similar Items