The Profile of Immunophenotype and Genotype Aberrations in Subsets of Pediatric T-Cell Acute Lymphoblastic Leukemia

The Profile of Immunophenotype and Genotype Aberrations in Subsets of Pediatric T-Cell Acute Lymphoblastic Leukemia

T-cell acute lymphoblastic leukemia (T-ALL) is a biologically heterogeneous malignancy, which reflects distinctive stages of T-cell differentiation arrest. We have revisited a cohort of pediatric T-ALL, in order to test if immunophenotypes associated with molecular alterations would predict the pati...

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Main Authors: Elda Pereira Noronha, Luísa Vieira Codeço Marques, Francianne Gomes Andrade, Luiz Claudio Santos Thuler, Eugênia Terra-Granado, Maria S. Pombo-de-Oliveira, Brazilian Collaborative Study Group of Acute Leukemia, Carolina da Paz Zampier, Marcela B. Mansur, Thayana da Conceição Barbosa, Paulo Chagas Neto, Gisele Dallapicola Brisson, Filipe Vicente dos Santos Bueno, Ingrid Cezar Sardou, Bruno Gonçalves Aguiar, Anna Carolina Silva Dias, Geraldo Pedral Sampaio, Raimundo Antônio Gomes Oliveira, Claudia Teresa de Oliveira, Cesar Casagranda, Geni Ramos Vera, Gustavo Ribeiro Neves, Isis Maria Quezado Magalhães, José Carlos Cordoba, Juliana Teixeira Costa, Patrícia Carneiro de Brito, Rebeca Ferreira Marques, Renata Pereira, Renato Guedes, Sidnei Epelman
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Oncology
Subjects:
T-cell acute lymphoblastic leukemia
childhood
immunophenotypic subtypes
molecular alterations
early T-cell precursor acute lymphoblastic leukemia
overall survival
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.00316/full

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https://www.frontiersin.org/article/10.3389/fonc.2019.00316/full

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