A genome-scale CRISPR Cas9 dropout screen identifies synthetically lethal targets in SRC-3 inhibited cancer cells

A genome-scale CRISPR Cas9 dropout screen identifies synthetically lethal targets in SRC-3 inhibited cancer cells

Using a CRISPR-based large-scale screen, Gilad et al. identify the genes that show synthetic lethality with an SRC-3 inhibitor in breast cancer cells while contrasting this with the estrogen receptor degrader fulvestrant. This study provides insights into the development of therapeutic strategies fo...

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Bibliographic Details
Main Authors: Yosi Gilad, Yossi Eliaz, Yang Yu, Adam M. Dean, San Jung Han, Li Qin, Bert W. O’Malley, David M. Lonard
Format: Article
Language:English
Published: Nature Publishing Group 2021-03-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-021-01929-1

Internet

https://doi.org/10.1038/s42003-021-01929-1

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