Exploiting hiPSCs in Leber's Hereditary Optic Neuropathy (LHON): Present Achievements and Future Perspectives

Exploiting hiPSCs in Leber's Hereditary Optic Neuropathy (LHON): Present Achievements and Future Perspectives

More than 30 years after discovering Leber's hereditary optic neuropathy (LHON) as the first maternally inherited disease associated with homoplasmic mtDNA mutations, we still struggle to achieve effective therapies. LHON is characterized by selective degeneration of retinal ganglion cells (RGC...

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Bibliographic Details
Main Authors: Camille Peron, Alessandra Maresca, Andrea Cavaliere, Angelo Iannielli, Vania Broccoli, Valerio Carelli, Ivano Di Meo, Valeria Tiranti
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Neurology
Subjects:
Leber's hereditary optic neuropathy
human induced pluripotent stem cells
mitochondrial disorders
organoids
retinal ganglion cells (RGC)
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2021.648916/full

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https://www.frontiersin.org/articles/10.3389/fneur.2021.648916/full

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