Targeting T Cell Activation and Lupus Autoimmune Phenotypes by Inhibiting Glucose Transporters

Targeting T Cell Activation and Lupus Autoimmune Phenotypes by Inhibiting Glucose Transporters

CD4+ T cells have numerous features of over-activated cellular metabolism in lupus patients and mouse models of the disease. This includes a higher glycolysis than in healthy controls. Glucose transporters play an essential role in glucose metabolism by controlling glucose import into the cell from...

Full description

Bibliographic Details
Main Authors: Wei Li, Ganlin Qu, Seung-Chul Choi, Caleb Cornaby, Anton Titov, Natalie Kanda, Xiangyu Teng, Haiting Wang, Laurence Morel
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Immunology
Subjects:
systemic lupus erythematosus
metabolism
glucose transporter
glycolysis
T cells
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00833/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00833/full

Similar Items