Yes-associated protein (YAP) and transcriptional coactivator with a PDZ-binding motif (TAZ): a nexus between hypoxia and cancer
Hypoxia is a common feature of solid tumors. As transcription factors, hypoxia-inducible factors (HIFs) are the master regulators of the hypoxic microenvironment; their target genes function in tumorigenesis and tumor development. Intriguingly, both yes-associated protein (YAP) and its paralog trans...
Main Authors: | Chenxi Zhao, Chenming Zeng, Song Ye, Xiaoyang Dai, Qiaojun He, Bo Yang, Hong Zhu |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2020-06-01
|
Series: | Acta Pharmaceutica Sinica B |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2211383519308214 |
Similar Items
-
Increased expression of yes-associated protein/YAP and transcriptional coactivator with PDZ-binding motif/TAZ activates intestinal fibroblasts to promote intestinal obstruction in Crohn's disease
by: Weijun Ou, et al.
Published: (2021-07-01) -
YAP/TAZ Activation as a Target for Treating Metastatic Cancer
by: Janine S. A. Warren, et al.
Published: (2018-04-01) -
A Potential Role of YAP/TAZ in the Interplay Between Metastasis and Metabolic Alterations
by: Hirohito Yamaguchi, et al.
Published: (2020-06-01) -
Defining mechanisms directing YAP/TAZ-mediated tumorigenesis
by: Hiemer, Samantha Elizabeth
Published: (2016) -
Mechanoregulation of YAP and TAZ in Cellular Homeostasis and Disease Progression
by: Xiaomin Cai, et al.
Published: (2021-05-01)