Duct- and Acinar-Derived Pancreatic Ductal Adenocarcinomas Show Distinct Tumor Progression and Marker Expression

Duct- and Acinar-Derived Pancreatic Ductal Adenocarcinomas Show Distinct Tumor Progression and Marker Expression

Summary: The cell of origin of pancreatic ductal adenocarcinoma (PDAC) has been controversial. Here, we show that identical oncogenic drivers trigger PDAC originating from both ductal and acinar cells with similar histology but with distinct pathophysiology and marker expression dependent on cell of...

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Bibliographic Details
Main Authors: Rute M.M. Ferreira, Rocio Sancho, Hendrik A. Messal, Emma Nye, Bradley Spencer-Dene, Richard K. Stone, Gordon Stamp, Ian Rosewell, Alberto Quaglia, Axel Behrens
Format: Article
Language:English
Published: Elsevier 2017-10-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717314134

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http://www.sciencedirect.com/science/article/pii/S2211124717314134

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