hERG K+ Channels Promote Survival of Irradiated Leukemia Cells

hERG K+ Channels Promote Survival of Irradiated Leukemia Cells

Many tumor cells express highly elevated activities of voltage-gated K+ channels in the plasma membrane which are indispensable for tumor growth. To test for K+ channel function during DNA damage response, we subjected human chronic myeloid leukemia (CML) cells to sub-lethal doses of ionizing radiat...

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Bibliographic Details
Main Authors: Daniela Palme, Milan Misovic, Katrin Ganser, Lukas Klumpp, Helmut R. Salih, Daniel Zips, Stephan M. Huber
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Pharmacology
Subjects:
ionizing radiation
patch-clamp whole-cell recording
flow cytometry
hERG1 potassium channels
S progression
G2/M arrest
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00489/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00489/full

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