New Cysteine Protease Inhibitors: Electrophilic (Het)arenes and Unexpected Prodrug Identification for the <i>Trypanosoma</i> Protease Rhodesain

New Cysteine Protease Inhibitors: Electrophilic (Het)arenes and Unexpected Prodrug Identification for the <i>Trypanosoma</i> Protease Rhodesain

Electrophilic (het)arenes can undergo reactions with nucleophiles yielding &#960;- or Meisenheimer (&#963;-) complexes or the products of the S<sub>N</sub>Ar addition/elimination reactions. Such building blocks have only rarely been employed for the design of enzyme inhibitors. H...

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Bibliographic Details
Main Authors: Philipp Klein, Patrick Johe, Annika Wagner, Sascha Jung, Jonas Kühlborn, Fabian Barthels, Stefan Tenzer, Ute Distler, Waldemar Waigel, Bernd Engels, Ute A. Hellmich, Till Opatz, Tanja Schirmeister
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Molecules
Subjects:
cysteine protease
rhodesain
electrophilic (het)arene
nucleophilic aromatic substitution
meisenheimer complex
π-complex
prodrug
Online Access:https://www.mdpi.com/1420-3049/25/6/1451

Internet

https://www.mdpi.com/1420-3049/25/6/1451

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