Hypoxia increases gefitinib-resistant lung cancer stem cells through the activation of insulin-like growth factor 1 receptor.

Hypoxia increases gefitinib-resistant lung cancer stem cells through the activation of insulin-like growth factor 1 receptor.

Accumulating evidence indicates that a small population of cancer stem cells (CSCs) is involved in intrinsic resistance to cancer treatment. The hypoxic microenvironment is an important stem cell niche that promotes the persistence of CSCs in tumors. Our aim here was to elucidate the role of hypoxia...

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Bibliographic Details
Main Authors: Akiko Murakami, Fumiyuki Takahashi, Fariz Nurwidya, Isao Kobayashi, Kunihiko Minakata, Muneaki Hashimoto, Takeshi Nara, Motoyasu Kato, Ken Tajima, Naoko Shimada, Shin-ichiro Iwakami, Mariko Moriyama, Hiroyuki Moriyama, Fumiaki Koizumi, Kazuhisa Takahashi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3904884?pdf=render

Internet

http://europepmc.org/articles/PMC3904884?pdf=render

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