Intracellular dynamics of Ataxin-2 in the human brains with normal and frontotemporal lobar degeneration with TDP-43 inclusions

Intracellular dynamics of Ataxin-2 in the human brains with normal and frontotemporal lobar degeneration with TDP-43 inclusions

Abstract TAR DNA-binding protein of 43 kDa (TDP-43) is a major component of intracellular aggregates formed in brains of the patients with frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS), which are correctively referred to as TDP-43 proteinopathies. A link between At...

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Bibliographic Details
Main Authors: Ryohei Watanabe, Shinji Higashi, Takashi Nonaka, Ito Kawakami, Kenichi Oshima, Kazuhiro Niizato, Haruhiko Akiyama, Mari Yoshida, Masato Hasegawa, Tetsuaki Arai
Format: Article
Language:English
Published: BMC 2020-10-01
Series:Acta Neuropathologica Communications
Subjects:
RNA-binding protein
Ataxin-2
Localization
TDP-43
Proteinopathy
Neurodegeneration
Online Access:http://link.springer.com/article/10.1186/s40478-020-01055-9

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http://link.springer.com/article/10.1186/s40478-020-01055-9

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