Dosage compensation in the mouse balances up-regulation and silencing of X-linked genes.
Dosage compensation in mammals involves silencing of one X chromosome in XX females and requires expression, in cis, of Xist RNA. The X to be inactivated is randomly chosen in cells of the inner cell mass (ICM) at the blastocyst stage of development. Embryonic stem (ES) cells derived from the ICM of...
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2007-12-01
|
Series: | PLoS Biology |
Online Access: | http://europepmc.org/articles/PMC2121114?pdf=render |