Dosage compensation in the mouse balances up-regulation and silencing of X-linked genes.

Dosage compensation in mammals involves silencing of one X chromosome in XX females and requires expression, in cis, of Xist RNA. The X to be inactivated is randomly chosen in cells of the inner cell mass (ICM) at the blastocyst stage of development. Embryonic stem (ES) cells derived from the ICM of...

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Bibliographic Details
Main Authors: Hong Lin, Vibhor Gupta, Matthew D Vermilyea, Francesco Falciani, Jeannie T Lee, Laura P O'Neill, Bryan M Turner
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-12-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC2121114?pdf=render