Characterization of the molecular changes associated with the overexpression of a novel epithelial cadherin splice variant mRNA in a breast cancer model using proteomics and bioinformatics approaches: identification of changes in cell metabolism and an increased expression of lactate dehydrogenase B

Characterization of the molecular changes associated with the overexpression of a novel epithelial cadherin splice variant mRNA in a breast cancer model using proteomics and bioinformatics approaches: identification of changes in cell metabolism and an increased expression of lactate dehydrogenase B

Abstract Background Breast cancer (BC) is the most common female cancer and the leading cause of cancer death in women worldwide. Alterations in epithelial cadherin (E-cadherin) expression and functions are associated to BC, but the underlying molecular mechanisms have not been fully elucidated. We...

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Bibliographic Details
Main Authors: Marina Rosso, Lara Lapyckyj, María José Besso, Marta Monge, Jaume Reventós, Francesc Canals, Jorge Oswaldo Quevedo Cuenca, María Laura Matos, Mónica Hebe Vazquez-Levin
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Cancer & Metabolism
Subjects:
Breast cancer
Epithelial cadherin
Alternative splicing
Epithelial to mesenchymal transition
Proteomic analysis
2D-DIGE
Online Access:http://link.springer.com/article/10.1186/s40170-019-0196-9

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http://link.springer.com/article/10.1186/s40170-019-0196-9

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