Impaired Vitamin D Signaling in T Cells From a Family With Hereditary Vitamin D Resistant Rickets

Impaired Vitamin D Signaling in T Cells From a Family With Hereditary Vitamin D Resistant Rickets

The active form of vitamin D, 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), mediates its immunomodulatory effects by binding to the vitamin D receptor (VDR). Here, we describe a new point mutation in the DNA-binding domain of the VDR and its consequences for 1,25(OH)2D3 signaling in T cells from heterozyg...

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Bibliographic Details
Main Authors: Fatima A. H. Al-Jaberi, Martin Kongsbak-Wismann, Alejandro Aguayo-Orozco, Nicolai Krogh, Terkild B. Buus, Daniel V. Lopez, Anna K. O. Rode, Eva Gravesen, Klaus Olgaard, Søren Brunak, Anders Woetmann, Niels Ødum, Charlotte M. Bonefeld, Carsten Geisler
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Immunology
Subjects:
vitamin D
vitamin D receptor
HVDRR
T cells
vitamin A
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.684015/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.684015/full

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