Adjuvant interferon-gamma immunotherapy in a patient with progressive cerebral Nocardia abscesses

Despite advances in medical care, mortality due to cerebral Nocardia abscesses remains unacceptably high. The case of a typical immunocompromised patient, who deteriorated clinically despite optimal antimicrobial treatment, is reported here. Adjuvant immunotherapy with interferon-gamma resulted in p...

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Main Authors:	Jenneke Leentjens, Mark S. Gresnigt, Frank L. van de Veerdonk, Matthijs Kox, Bart Jan Kullberg, Peter Pickkers, Annemarie E. Brouwer, Mihai G. Netea
Format:	Article
Language:	English
Published:	Elsevier 2017-06-01
Series:	International Journal of Infectious Diseases
Subjects:	Nocardiosis Nocardia Cerebral abscess IFN-gamma Immunotherapy
Online Access:	http://www.sciencedirect.com/science/article/pii/S1201971217300966

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spelling	doaj-6fefee6594ab489c907e61263460834f2020-11-25T00:48:38ZengElsevierInternational Journal of Infectious Diseases1201-97121878-35112017-06-0159C252810.1016/j.ijid.2017.03.013Adjuvant interferon-gamma immunotherapy in a patient with progressive cerebral Nocardia abscessesJenneke Leentjens0Mark S. Gresnigt1Frank L. van de Veerdonk2Matthijs Kox3Bart Jan Kullberg4Peter Pickkers5Annemarie E. Brouwer6Mihai G. Netea7Department of Internal Medicine, Radboud university medical center, Radboud Institute for Molecular Life Sciences (RILMS), Nijmegen, the NetherlandsDepartment of Internal Medicine, Radboud university medical center, Radboud Institute for Molecular Life Sciences (RILMS), Nijmegen, the NetherlandsDepartment of Internal Medicine, Radboud university medical center, Radboud Institute for Molecular Life Sciences (RILMS), Nijmegen, the NetherlandsDepartment of Intensive Care Medicine, Radboud university medical center, Radboud Institute for Molecular Life Sciences (RILMS), Nijmegen, the NetherlandsDepartment of Internal Medicine, Radboud university medical center, Radboud Institute for Molecular Life Sciences (RILMS), Nijmegen, the NetherlandsDepartment of Intensive Care Medicine, Radboud university medical center, Radboud Institute for Molecular Life Sciences (RILMS), Nijmegen, the NetherlandsDepartment of Internal Medicine, Elisabeth Hospital, Tilburg, the NetherlandsDepartment of Internal Medicine, Radboud university medical center, Radboud Institute for Molecular Life Sciences (RILMS), Nijmegen, the NetherlandsDespite advances in medical care, mortality due to cerebral Nocardia abscesses remains unacceptably high. The case of a typical immunocompromised patient, who deteriorated clinically despite optimal antimicrobial treatment, is reported here. Adjuvant immunotherapy with interferon-gamma resulted in partial restoration of the immune response and a corresponding clinical and radiographic recovery.http://www.sciencedirect.com/science/article/pii/S1201971217300966NocardiosisNocardiaCerebral abscessIFN-gammaImmunotherapy
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Jenneke Leentjens Mark S. Gresnigt Frank L. van de Veerdonk Matthijs Kox Bart Jan Kullberg Peter Pickkers Annemarie E. Brouwer Mihai G. Netea
spellingShingle	Jenneke Leentjens Mark S. Gresnigt Frank L. van de Veerdonk Matthijs Kox Bart Jan Kullberg Peter Pickkers Annemarie E. Brouwer Mihai G. Netea Adjuvant interferon-gamma immunotherapy in a patient with progressive cerebral Nocardia abscesses International Journal of Infectious Diseases Nocardiosis Nocardia Cerebral abscess IFN-gamma Immunotherapy
author_facet	Jenneke Leentjens Mark S. Gresnigt Frank L. van de Veerdonk Matthijs Kox Bart Jan Kullberg Peter Pickkers Annemarie E. Brouwer Mihai G. Netea
author_sort	Jenneke Leentjens
title	Adjuvant interferon-gamma immunotherapy in a patient with progressive cerebral Nocardia abscesses
title_short	Adjuvant interferon-gamma immunotherapy in a patient with progressive cerebral Nocardia abscesses
title_full	Adjuvant interferon-gamma immunotherapy in a patient with progressive cerebral Nocardia abscesses
title_fullStr	Adjuvant interferon-gamma immunotherapy in a patient with progressive cerebral Nocardia abscesses
title_full_unstemmed	Adjuvant interferon-gamma immunotherapy in a patient with progressive cerebral Nocardia abscesses
title_sort	adjuvant interferon-gamma immunotherapy in a patient with progressive cerebral nocardia abscesses
publisher	Elsevier
series	International Journal of Infectious Diseases
issn	1201-9712 1878-3511
publishDate	2017-06-01
description	Despite advances in medical care, mortality due to cerebral Nocardia abscesses remains unacceptably high. The case of a typical immunocompromised patient, who deteriorated clinically despite optimal antimicrobial treatment, is reported here. Adjuvant immunotherapy with interferon-gamma resulted in partial restoration of the immune response and a corresponding clinical and radiographic recovery.
topic	Nocardiosis Nocardia Cerebral abscess IFN-gamma Immunotherapy
url	http://www.sciencedirect.com/science/article/pii/S1201971217300966
work_keys_str_mv	AT jennekeleentjens adjuvantinterferongammaimmunotherapyinapatientwithprogressivecerebralnocardiaabscesses AT marksgresnigt adjuvantinterferongammaimmunotherapyinapatientwithprogressivecerebralnocardiaabscesses AT franklvandeveerdonk adjuvantinterferongammaimmunotherapyinapatientwithprogressivecerebralnocardiaabscesses AT matthijskox adjuvantinterferongammaimmunotherapyinapatientwithprogressivecerebralnocardiaabscesses AT bartjankullberg adjuvantinterferongammaimmunotherapyinapatientwithprogressivecerebralnocardiaabscesses AT peterpickkers adjuvantinterferongammaimmunotherapyinapatientwithprogressivecerebralnocardiaabscesses AT annemarieebrouwer adjuvantinterferongammaimmunotherapyinapatientwithprogressivecerebralnocardiaabscesses AT mihaignetea adjuvantinterferongammaimmunotherapyinapatientwithprogressivecerebralnocardiaabscesses
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Adjuvant interferon-gamma immunotherapy in a patient with progressive cerebral Nocardia abscesses

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