Adrenomedullin and Adrenomedullin-Targeted Therapy As Treatment Strategies Relevant for Sepsis

by Christopher Geven, Christopher Geven, Matthijs Kox, Matthijs Kox, Peter Pickkers, Peter Pickkers
Published 2018-02-01

Precision Immunotherapy for Sepsis

by Annemieke M. Peters van Ton, Matthijs Kox, Matthijs Kox, Wilson F. Abdo, Peter Pickkers, Peter Pickkers
Published 2018-09-01

Comparison of different lots of endotoxin and evaluation of potency over time in the experimental human endotoxemia model

by Dorien Kiers, Guus P. Leijte, Jelle Gerretsen, Jelle Zwaag, Matthijs Kox, Peter Pickkers
Published 2019-01-01

The effects of orally administered Beta-glucan on innate immune responses in humans, a randomized open-label intervention pilot-study.

by Jenneke Leentjens, Jessica Quintin, Jelle Gerretsen, Matthijs Kox, Peter Pickkers, Mihai G Netea
Published 2014-01-01

Increased Plasma Levels of Danger-Associated Molecular Patterns Are Associated With Immune Suppression and Postoperative Infections in Patients Undergoing Cytoreductive Surgery and...

by Guus P. Leijte, Guus P. Leijte, Hettie Custers, Jelle Gerretsen, Jelle Gerretsen, Amon Heijne, Johannes Roth, Thomas Vogl, Gert J. Scheffer, Peter Pickkers, Peter Pickkers, Matthijs Kox, Matthijs Kox
Published 2018-04-01

Endotoxemia-Induced Release of Pro-inflammatory Mediators Are Associated With Increased Glomerular Filtration Rate in Humans in vivo

by Remi Beunders, Remi Beunders, Remi Beunders, Maren J. Schütz, Roger van Groenendael, Roger van Groenendael, Roger van Groenendael, Guus P. Leijte, Guus P. Leijte, Guus P. Leijte, Matthijs Kox, Matthijs Kox, Matthijs Kox, Lucas T. van Eijk, Lucas T. van Eijk, Lucas T. van Eijk, Peter Pickkers, Peter Pickkers, Peter Pickkers
Published 2020-11-01

Increased blood angiotensin converting enzyme 2 activity in critically ill COVID-19 patients

by Dirk van Lier, Matthijs Kox, Karine Santos, Hans van der Hoeven, Janesh Pillay, Peter Pickkers
Published 2021-03-01

The chicken or the egg: low testosterone predisposes for COVID-19 or COVID-19 induces a decrease in testosterone?

by Roeland F. Stolk, Henk J. van Leeuwen, Matthijs Kox, Marcel van Borren, Hans de Boer, Peter Pickkers
Published 2021-07-01

Biomarkers for antimicrobial stewardship: a reappraisal in COVID-19 times?

by Miranda van Berkel, Matthijs Kox, Tim Frenzel, Peter Pickkers, Jeroen Schouten, on behalf of the RCI-COVID-19 study group
Published 2020-10-01

Effects of vagus nerve stimulation and vagotomy on systemic and pulmonary inflammation in a two-hit model in rats.

by Matthijs Kox, Michiel Vaneker, Johannes G van der Hoeven, Gert-Jan Scheffer, Cornelia W Hoedemaekers, Peter Pickkers
Published 2012-01-01

Monocytic HLA-DR expression kinetics in septic shock patients with different pathogens, sites of infection and adverse outcomes

by Guus P. Leijte, Thomas Rimmelé, Matthijs Kox, Niklas Bruse, Céline Monard, Morgane Gossez, Guillaume Monneret, Peter Pickkers, Fabienne Venet
Published 2020-03-01

Gamma-Irradiated Bacille Calmette-Guérin Vaccination Does Not Modulate the Innate Immune Response during Experimental Human Endotoxemia in Adult Males

by Linda A. C. Hamers, Matthijs Kox, Rob J. W. Arts, Bastiaan Blok, Jenneke Leentjens, Mihai G. Netea, Peter Pickkers
Published 2015-01-01

No interplay between gut microbiota composition and the lipopolysaccharide‐induced innate immune response in humans in vivo

by Quirine LM Habes, Prokopis Konstanti, Harmke D Kiers, Rebecca M Koch, Roeland F Stolk, Clara Belzer, Matthijs Kox, Peter Pickkers
Published 2021-01-01

Adjuvant interferon-gamma immunotherapy in a patient with progressive cerebral Nocardia abscesses

by Jenneke Leentjens, Mark S. Gresnigt, Frank L. van de Veerdonk, Matthijs Kox, Bart Jan Kullberg, Peter Pickkers, Annemarie E. Brouwer, Mihai G. Netea
Published 2017-06-01

IFN-γ-stimulated neutrophils suppress lymphocyte proliferation through expression of PD-L1.

by Stan de Kleijn, Jeroen D Langereis, Jenneke Leentjens, Matthijs Kox, Mihai G Netea, Leo Koenderman, Gerben Ferwerda, Peter Pickkers, Peter W M Hermans
Published 2013-01-01

COVID-19 patients exhibit less pronounced immune suppression compared with bacterial septic shock patients

by Matthijs Kox, Tim Frenzel, Jeroen Schouten, Frank L. van de Veerdonk, Hans J. P. M. Koenen, Peter Pickkers, , on behalf of the RCI-COVID-19 study group
Published 2020-05-01

Involvement of Lactate and Pyruvate in the Anti-Inflammatory Effects Exerted by Voluntary Activation of the Sympathetic Nervous System

by Jelle Zwaag, Rob ter Horst, Ivana Blaženović, Daniel Stoessel, Jacqueline Ratter, Josephine M. Worseck, Nicolas Schauer, Rinke Stienstra, Mihai G. Netea, Dieter Jahn, Peter Pickkers, Matthijs Kox
Published 2020-04-01

Short-term repeated HRV-16 exposure results in an attenuated immune response in vivo in humans.

by Rebecca M Koch, Matthijs Kox, Corné van den Kieboom, Gerben Ferwerda, Jelle Gerretsen, Sandra Ten Bruggencate, Johannes G van der Hoeven, Marien I de Jonge, Peter Pickkers
Published 2018-01-01

Systemic inflammation decreases pain threshold in humans in vivo.

by Moniek de Goeij, Lucas T van Eijk, Pascal Vanelderen, Oliver H Wilder-Smith, Kris C Vissers, Johannes G van der Hoeven, Matthijs Kox, Gert Jan Scheffer, Peter Pickkers
Published 2013-01-01

Increased Plasma Heparanase Activity in COVID-19 Patients

by Baranca Buijsers, Cansu Yanginlar, Aline de Nooijer, Inge Grondman, Marissa L. Maciej-Hulme, Inge Jonkman, Nico A. F. Janssen, Nils Rother, Mark de Graaf, Peter Pickkers, Peter Pickkers, Matthijs Kox, Matthijs Kox, Leo A. B. Joosten, Tom Nijenhuis, Mihai G. Netea, Mihai G. Netea, Luuk Hilbrands, Frank L. van de Veerdonk, Raphaël Duivenvoorden, Raphaël Duivenvoorden, Quirijn de Mast, Johan van der Vlag
Published 2020-10-01