Anatomical transcriptome of G protein-coupled receptors leads to the identification of a novel therapeutic candidate GPR52 for psychiatric disorders.

Anatomical transcriptome of G protein-coupled receptors leads to the identification of a novel therapeutic candidate GPR52 for psychiatric disorders.

Many drugs of abuse and most neuropharmacological agents regulate G protein-coupled receptors (GPCRs) in the central nervous system (CNS)_ENREF_1. The striatum, in which dopamine D1 and D2 receptors are enriched, is strongly innervated by the ventral tegmental area (VTA), which is the origin of dopa...

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Main Authors: Hidetoshi Komatsu, Minoru Maruyama, Shuuhei Yao, Tokuyuki Shinohara, Kensuke Sakuma, Sachiko Imaichi, Tomoko Chikatsu, Kanako Kuniyeda, Foo Kok Siu, Lam Sock Peng, Katherine Zhuo, Lay Sock Mun, Tan Min Han, Yoshio Matsumoto, Tadatoshi Hashimoto, Nobuyuki Miyajima, Yasuaki Itoh, Kazuhiro Ogi, Yugo Habata, Masaaki Mori
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3938596?pdf=render

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http://europepmc.org/articles/PMC3938596?pdf=render

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