Ancestry-specific associations identified in genome-wide combined-phenotype study of red blood cell traits emphasize benefits of diversity in genomics

Ancestry-specific associations identified in genome-wide combined-phenotype study of red blood cell traits emphasize benefits of diversity in genomics

Abstract Background Quantitative red blood cell (RBC) traits are highly polygenic clinically relevant traits, with approximately 500 reported GWAS loci. The majority of RBC trait GWAS have been performed in European- or East Asian-ancestry populations, despite evidence that rare or ancestry-specific...

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Bibliographic Details
Main Authors: Chani J. Hodonsky, Antoine R. Baldassari, Stephanie A. Bien, Laura M. Raffield, Heather M. Highland, Colleen M. Sitlani, Genevieve L. Wojcik, Ran Tao, Marielisa Graff, Weihong Tang, Bharat Thyagarajan, Steve Buyske, Myriam Fornage, Lucia A. Hindorff, Yun Li, Danyu Lin, Alex P. Reiner, Kari E. North, Ruth J. F. Loos, Charles Kooperberg, Christy L. Avery
Format: Article
Language:English
Published: BMC 2020-03-01
Series:BMC Genomics
Subjects:
Blood cell traits
Combined-phenotype analysis
Pleiotropy
Diversity
Multi-ethnic
GWAS
Online Access:http://link.springer.com/article/10.1186/s12864-020-6626-9

Internet

http://link.springer.com/article/10.1186/s12864-020-6626-9

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