Modulation of Cancer-Associated Fibrotic Stroma by An Integrin αvβ3 Targeting Protein for Pancreatic Cancer TreatmentSummary

Modulation of Cancer-Associated Fibrotic Stroma by An Integrin αvβ3 Targeting Protein for Pancreatic Cancer TreatmentSummary

Background & Aims: Pancreatic ductal adenocarcinoma (PDAC) is resistant to most therapeutics owing to dense fibrotic stroma orchestrated by cancer-associated pancreatic stellate cells (CAPaSC). CAPaSC also support cancer cell growth, metastasis, and resistance to apoptosis. Currently, there...

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Bibliographic Details
Main Authors: Ravi Chakra Turaga, Malvika Sharma, Falguni Mishra, Alyssa Krasinskas, Yi Yuan, Jenny J. Yang, Shiyuan Wang, Chunfeng Liu, Sun Li, Zhi-Ren Liu
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Cellular and Molecular Gastroenterology and Hepatology
Subjects:
Pancreatic Cancer Treatment
Pancreatic Stellate Cells
Integrin αvβ3
Collagen
Gemcitabine
Online Access:http://www.sciencedirect.com/science/article/pii/S2352345X20301284

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http://www.sciencedirect.com/science/article/pii/S2352345X20301284

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