An integrated in silico approach to design specific inhibitors targeting human poly(a)-specific ribonuclease.

An integrated in silico approach to design specific inhibitors targeting human poly(a)-specific ribonuclease.

Poly(A)-specific ribonuclease (PARN) is an exoribonuclease/deadenylase that degrades 3'-end poly(A) tails in almost all eukaryotic organisms. Much of the biochemical and structural information on PARN comes from the human enzyme. However, the existence of PARN all along the eukaryotic evolution...

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Bibliographic Details
Main Authors: Dimitrios Vlachakis, Athanasia Pavlopoulou, Georgia Tsiliki, Dimitri Komiotis, Constantinos Stathopoulos, Nikolaos A A Balatsos, Sophia Kossida
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23236441/?tool=EBI

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23236441/?tool=EBI

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