An integrated in silico approach to design specific inhibitors targeting human poly(a)-specific ribonuclease.
Poly(A)-specific ribonuclease (PARN) is an exoribonuclease/deadenylase that degrades 3'-end poly(A) tails in almost all eukaryotic organisms. Much of the biochemical and structural information on PARN comes from the human enzyme. However, the existence of PARN all along the eukaryotic evolution...
Main Authors: | Dimitrios Vlachakis, Athanasia Pavlopoulou, Georgia Tsiliki, Dimitri Komiotis, Constantinos Stathopoulos, Nikolaos A A Balatsos, Sophia Kossida |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2012-01-01
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Series: | PLoS ONE |
Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23236441/?tool=EBI |
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