Conformational landscape of multidomain SMAD proteins

Conformational landscape of multidomain SMAD proteins

SMAD transcription factors, the main effectors of the TGFβ (transforming growth factor β) network, have a mixed architecture of globular domains and flexible linkers. Such a complicated architecture precluded the description of their full-length (FL) structure for many years. In this study, we unrav...

Full description

Bibliographic Details
Main Authors: Tiago Gomes, Pau Martin-Malpartida, Lidia Ruiz, Eric Aragón, Tiago N. Cordeiro, Maria J. Macias
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Intrinsically disordered regions
Multi-domain proteins
SMAD
Transcription factor
TGFβ signaling
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037021003949

Internet

http://www.sciencedirect.com/science/article/pii/S2001037021003949

Similar Items