Conformational landscape of multidomain SMAD proteins
SMAD transcription factors, the main effectors of the TGFβ (transforming growth factor β) network, have a mixed architecture of globular domains and flexible linkers. Such a complicated architecture precluded the description of their full-length (FL) structure for many years. In this study, we unrav...
Main Authors: | Tiago Gomes, Pau Martin-Malpartida, Lidia Ruiz, Eric Aragón, Tiago N. Cordeiro, Maria J. Macias |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2021-01-01
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Series: | Computational and Structural Biotechnology Journal |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2001037021003949 |
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